Quantum Interfaces to the Nanoscale

Here, we offer our perspective on how defect centers can mediate the transfer of quantum information between many leading qubit platforms.

4-Hydroxybutyrate Promotes Endogenous Antimicrobial Peptide Expression in Macrophages

Antimicrobial peptides largely avoid resistance acquired by bacteria to man-made antibiotics. Here, we develop a surgical mesh composed of a novel polymer that increases resistance to bacterial contamination compared to a more traditional surgical polymer.

The Effect of Mechanical Loading Upon Extracellular Matrix Bioscaffold-Mediated Skeletal Muscle Remodeling

It is challenging to regenerate large volumes of lost muscle. Here, we show that implanting extracellular matrix, or what's leftover after cells are removed from tissue and organs, in muscle in conjunction with stretching and flexing the affected region can improve health outcomes.

Scalable “Dip-and-Dry” Fabrication of a Wide-Angle Plasmonic Selective Absorber for High-Efficiency Solar–Thermal Energy Conversion

Sunlight is an abundant source of energy, but converting it into electricity via photovoltaics can be costly. Here, we discover a cheaply synthesized and stable nanomaterial that efficiently converts sunlight directly into heat (much like a seatbelt buckle during hot summer months!)

Upconverting Nanoparticles as Optical Sensors of Nano- to Micro- Newton Forces

The ability to measure mechanical forces acting on very small objects, such as individual cells or fibers in nanocomposites, would help scientists understand, engineer, and control them. Here, we synthesize nanoparticles that change color in response to mechanical forces.

Direct Intracellular Delivery of Cell-Impermeable Probes of Protein Glycosylation by Using Nanostraws

Metabolic labeling has become an essential tool for tracking the passage and function of biological substrates, yet it is limited by the difficulty of cellular delivery. Here, we show that nanostraws can deliver membrane-impermeable metabolic probes directly into cells.

Engineering a Dual-Layer Chitosan-Lactide Hydrogel To Create Endothelial Cell Aggregate-Induced Microvascular Networks In Vitro and Increase Blood Perfusion In Vivo

Tissue regenerating-cells are sensitive to their environment. Here, we engineer hydrogels with varying degradation times and stiffnesses, load them with cells, and show that the hydrogen can induce cells to aggregate into microvascular networks that enhance blood flow in a mouse model.

Temporally resolved direct delivery of second messengers into cells using nanostraws

Transporting biomolecules into cells is an essential tool to manipulate biological signaling cascades, but certain biomolecules, such as second messengers, are difficult to transport. Here, we show that nanostraws can penetrate the cell membrane and deliver second messengers directly into the cell, opening the possibility for time-resolved delivery of any freely diffusing molecules.